I have a couple of questions regarding weighted linear regression that i will be using for the data analysis of my research work. I work in the area of Analytical chemistry, but i have to do a lot of data analysis stuff that includes linear regression (finding the best fit line and the corresponding slope, intercept etc.).Please share your opinions regarding my following questions.

1. Suppose i have an independent variable "X" and a dependent variable "Y". For different values of X and Y, I can obtain a best fit line in Microsoft Excel without using any weighting. How can i obtain a best fit line if i use a weighting scheme such as 1/x , 1/x/x , etc. ? Are there any free Statistical softwares available for drawing these best fit lines?

2. Also, in my research i will be having some baseline value of "Y" when X=0 (for example, for x=0, y = 10 units). In such a case, how is the weighting considered when x=0 ? I have this question because 1/x, 1/x/x cannot be defined when x=0 . How do these statistical softwares consider weighting in such a case? Will these softwares ignore the point (x,y) when x=0? What is the right thing to do in such a scenario?

Please provide information to the concerned questions.

Thanks,

Sai