In a clinical trail, 60 patients involved in a study, all of them are suffering from a brain injury.

30 patients got "NewDrug" and 30 got "Placebo".

I need to assess the efficacy of the drug treatment by comparison with the placebo treated by statistical significance testing for the entire sample.

I have a table for the placebo group, where first column has the data of the values of the volume of injury before receivingplacebo, second column has values of the volume injury after receiving placebo, and the third column with the differences (column 1 - column 2)

The same table for the newdrug group, where first column has the data of the values of the volume of injury before receivingdrug, second column has values of the volume injury after receiving drug, and the third column with the differences (column 1 - column 2).

I dont know which test to use ? is it paried or un-paried t-test (i tried to do paried t-test but i dont know what to write in the null hypothesis and alternative hypothesis), so if someone can help me with that it will be great!