Results 1 to 2 of 2

Thread: Calculate significance of difference in count numbers between populations

  1. #1
    pjk is offline
    Nov 2012

    probability of count numbers between populations difference


    I'm comparing genomic distribution counts of two subsets of a dataset that were composed using different selection criteria.

    Both subsets contain x values corresponding to the genomic startpositions of probes used on an array to assess the status of specific sequences on the genome.

    subset1 subset2
    a: 8281 -- 31225
    b: 6323 -- 7853
    c: 1397 -- 711
    d: 2462 -- 2205
    e: 2397 -- 2351
    f: 4120 -- 317
    g: 12756 -- 2659
    h: 12255 -- 2679
    total: 50000 -- 49991

    The table above lists the number of counts per genomic category (a-h) of the two subsets. Here, subset1 represents a set of startpositions of randomly selected probes and subset 2 a set of probes that were selected according to a specific criterium.
    I now want to determine whether the difference in count numbers is significant for categories individually. Basically, I would like to stastically demonstrate that 31225 does, or does not significantly differ from 8281 if the latter number is to be expected for this category when probes are selected at random.

    Thanks in advance,

    Last edited by pjk; Nov 5th 2012 at 01:43 AM.
    Follow Math Help Forum on Facebook and Google+

  2. #2
    MHF Contributor
    Sep 2012

    Re: Calculate significance of difference in count numbers between populations

    Hey pjk.

    You can test the difference of proportions from two samples using a two-sample t-test which you might want to consider.
    Follow Math Help Forum on Facebook and Google+

Similar Math Help Forum Discussions

  1. Count numbers greater than a given number
    Posted in the Math Software Forum
    Replies: 1
    Last Post: Jan 24th 2011, 02:56 PM
  2. Replies: 2
    Last Post: Jan 10th 2011, 06:42 PM
  3. Replies: 2
    Last Post: Sep 2nd 2010, 11:52 AM
  4. [SOLVED] Calculate at Difference %
    Posted in the Algebra Forum
    Replies: 1
    Last Post: Apr 16th 2009, 05:49 AM
  5. Minimum Significance Difference
    Posted in the Advanced Statistics Forum
    Replies: 0
    Last Post: Jan 26th 2007, 06:11 AM

Search Tags

/mathhelpforum @mathhelpforum