How to set up this T-test

Need some help setting up a statistical analysis for a project. I'm going to try to just give an example similar to my project rather than take the time to explain it (not that it's that complicated. it would just require a lengthy explanation). Here goes.

Let's say I have an instrument that's measuring the distance from itself to an object that is in motion. The instrument takes measurements every second and records it. I run the exact same test four times with the object following exactly the same path every time. Unfortunately, I wind up with four slightly different sets of data. I want to evaluate the performance of the instrument by comparing these four sets.

My professor told me I should use a T-Test. I'm fairly certain that I have to pick two sets of data at a time and acquire the difference between the two at each point in time in order to eliminate one of the variables (instead of time and the actual location of the object, the only variable will be time). I want to see if the difference between two (or more) of these sets is significant and use either a 90% or 95% confidence interval. Can anybody help me set this up? I haven't done this kind of stuff in a long time and I can't quite figure it out.

My data is all in excel and ready to go. I just need some guidance. Btw, there are about 1500 points in each set so I wouldn't be able to post my info.

Thanks!