yes'i got it by a direct computation/
Thank's
I think that I post this before. If $\ell_1: P+t\vec{D} ~\&~\ell_2: Q+t\vec{E}$ are shew lines then there is a unique perpendicular them.
The distance between the two lines is $d(\ell_1,\ell_2)=\dfrac{|\overrightarrow {PQ} \cdot (\vec{D} \times \vec{E})|}{\|\vec{D}\times \vec{E}\|}$
To find the endpoints of that common perpendicular is both tricky & tedious. SEE HERE
The vector $\vec{N}=\vec{D}\times\vec{E}$ the normal for the plane you want.
Since the OP has solved the problem, I will point out that alternatively, if $\vec R_1 = \vec P +t\vec D$ and $\vec R_2 = \vec Q + s\vec E$ then the midpoint between them is $$
\vec M = \frac 1 2(\vec R_1 + \vec R_2) = \frac 1 2(\vec P + \vec Q) + \frac 1 2 t\vec D + \frac 1 2 s\vec E$$which is a parametric representation of the "mid" plane if $\vec D$ and $\vec E$ are not parallel.