Which letter comes next?
A C F J O
The letters between A and C:
B
The letters between C and F:
DE
The letters between F and J:
GHI
The letters between J and O:
KLMN
We can see that the number of letters between each letter in the sequence increases by adding the next letter. Therefore, one can deduce that the letters between O and the next letter are:
PQRST
revealing that the unknown letter is U.