Please solve the problem.

The following formula accurately models the relationship between the size of a certain type of tumor and the amount of time that it has been growing:

V(t) = 450[1 - e^(-.0017t)]^3

where t is in months and V(t) is measured in cubic centimeters. Calculate the rate of change of tumor volume at 180 months.

I think I need to differentiate the formula and substitute 180 for t.

But I don't know how to differentiate this formula because there's e and seems complicated...