Using the quotient rule:
I'll leave the simplification to you
Begin by dividing each of the three terms in the numerator (top) by the term in the denominator.
Before you do this, here are a few things you'll need to know about handling indices (powers):
First, then, divide by like this:
Now divide by , and then divide by in the same way.
You'll then have three separate terms in which you can differentiate in the usual way.
Hope that helps.