Think of the quartic root as, instead, being a 1/4 power (square roots are 1/2 power, cube roots are 1/3 power, etc.) So now your expression becomes:
You can move your denominator into the numerator simply by making the exponent negative, giving:
Now, you can differentiate this using the power rule in combination with the chain rule. Bring the power down and reduce it by 1 - this makes your new exponent (-5/4). Also, the chain rule says you have to take the derivative of "the inside function," here the 9x^2+4 portion.
This gives 3*(-1/4)(9x^2+4)^(-5/4)*(18x).
Reading left to right, the 3 is the original constant you had;
the (-1/4) is the power you brought down via the power rule;
the (9x^2+4)^(-5/4) is basically your original fourth-root, put in the numerator, with the power reduced by 1;
the 18x is the derivative of 9x^2+4, present because of the chain rule.
You can simplify a little bit, of course, but that takes care of the differentiation.
Hope this helps!