Given x + (4/x) finding the difference quotient I am wondering how to get started.

I don't know why but, for the life of me I can't clear the fractions and I keep thinking no matter what I do i'm not going to end up with like denominators.

I have gotten use to doing difference quotient by itself.. but, given whole's and fractions here my head is sorta spinning... I haven't missed the D.Q. much at all lately thats for sure.