Someone wants to give you an ulcer, don't they?

Simplify first:

I'm going to expand the numerator so my next step will be a bit clearer:

Now mulitply the numerator and denominator by x^4. We would normally need to be wary of doing this, but the domain of the original function excludes x = 0 anyway in this case.

You should be able to take the derivative now.

-Dan