What exactly is troubling you? You're familiar with basic derivatives, right?
Your problem is find dy/dx, given that
To start, you need to differentiate every term in that equation. The first and the last one are straightforward, but the middle term, is trickier. You must remember to multiply by dy/dx at the end of the normal derivative we are assuming y is really y(x), meaning a function of x.
Anyway, show me what you can do and we'll get through it.