Hey guys, I'm having a hard time trying to figure out how to simplify this:

*Problem is attached* If you can't use that it's here:

6x(2x+1)^1/4 (x^2+1)^2 + .5(2x+1)^-3/4 (x^2+1)^3

I need a start, and I'm assuming it's with the exponents but I can't figure it out for my life. (Headbang)

Thanks for any help guys.