Results 1 to 2 of 2

Math Help - Help with stats interpretation!! Odds Ratio in dose-response model

  1. #1
    Newbie
    Joined
    Sep 2012
    From
    Australia
    Posts
    4

    Help with stats interpretation!! Odds Ratio in dose-response model

    Hi all
    just wondering if someone can please help me understand this a bit better. I am reading an article and I am soooo confused about the odds ratios. I'm not very good at all this stats stuff. Any help is much appreciated!

    The paper is looking at serum TSH (blood test) and the relationship between risk of thyroid cancer - they found that higher TSH is associated with a higher risk of thyroid cancer.

    In the non linear dose response meta-analysis, they said all models tested showed a positive response between TSH and OR for thyroid cancer, all non linear models (showing interaction of the relationship by differing TSH levels) explained the data better than conventional linear models. Spline models (allowing a change in magnitude of thyroid cancer-serum TSH relationship at a given TSH concentration) were the best fitting; with a change occuring at serum TSH = 1mU/L.

    **Now this is the bit I don't understand:**
    The OR for TSH below 1 mU/L was 1.72 (1.42, 2.07) per milliunit per litre, but above this TSH level became 1.16 (1.12, 1.21) per milliunit per litre of higher serum TSH.

    Are they saying that as your TSH is lower than 1, you are 1.72 more times likely to get thyroid cancer per miliunit less than 1?
    And as your TSH is greater than 1, for each miliunit greater, you are 1.16 times likely to get thyroid cancer?

    But with the conclusion that the greater the TSH, the greater cancer risk, I would have thought that the OR should be greater for a TSH > 1 vs TSH < 1?
    Can someone please explain this to me? If it helps I can email the article but I think I should have put enough info in here

    thanks
    Jen
    Follow Math Help Forum on Facebook and Google+

  2. #2
    Newbie
    Joined
    Sep 2012
    From
    Australia
    Posts
    4

    Re: Help with stats interpretation!! Odds Ratio in dose-response model

    Is it maybe talking about rate of change of TSH risk is greater at smaller TSH?

    They said that 'putting it into perspective, the model predicts that the odds of thyroid cancer is 3x greater in a patient with a TSH of 4 mU/L compared with TSH of 0. Within the normal range, the model predicts a doubling of odds of thyroid cancer between a TSH of 0.65-4 mU/L; from a normal range to an elevated TSH there is a doubling of odds of thyroid cancer between a serum TSH of 2.2 and 7 mU/L.
    Follow Math Help Forum on Facebook and Google+

Similar Math Help Forum Discussions

  1. Replies: 1
    Last Post: September 11th 2012, 02:52 AM
  2. Logistics Regression: Odds Ratio for model with interactions
    Posted in the Advanced Statistics Forum
    Replies: 1
    Last Post: August 9th 2010, 02:54 AM
  3. Bayes Binomial-Beta Posterior Odds Ratio
    Posted in the Advanced Statistics Forum
    Replies: 0
    Last Post: April 16th 2009, 07:29 PM
  4. Spring Model Interpretation!
    Posted in the Advanced Applied Math Forum
    Replies: 0
    Last Post: November 2nd 2008, 08:07 AM
  5. Normal Model...stats
    Posted in the Advanced Statistics Forum
    Replies: 1
    Last Post: March 26th 2008, 04:51 AM

Search Tags


/mathhelpforum @mathhelpforum